Hydrocortisone (HC) has formed the mainstay for the management of atopic dermatitis.Hence, HC-loaded chitosan nanoparticles\r\nwere prepared by ionic crosslinking of high, low molecular weight chitosan (HMwt, LMwt CS) and N-trimethyl chitosan (TMC)\r\nwith tripolyphosphate. HC loading into CS nanoparticles was confirmed by FT-IR. The particle size of HC-loaded HMwt, LMwt,\r\nand TMC nanoparticles was increased from 243�±12, 147�±11, and 124�±9 nmto 337�±13, 222�±14, and 195�±7 nm, respectively, by\r\nincreasing the pH of CS solution. Their respective zeta potential and entrapment efficiency (EE) were significantly decreased by\r\nincreasing the pH of CS solution. The swelling ratios of HC loaded HMwt, LMwt, and TMC NPs were increased when the pH of\r\nincubating media (PBS) was increased. The same increasing trend was observed in particle size and EE of HC loaded as the CS\r\nconcentration was increased. The HC loaded CS NPs were generally nonspherical. In-vitro permeation studies showed that HC was\r\nefficiently released from the CS NPs in QV cream while in aqueous cream CS NPs provided a sustained release for HC. Thus, it is\r\nanticipated that CS NPs are the promising delivery system for anti-inflammatory drugs.
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